The use of Diacarb in intracranial pressure

Diacarb (Acetazolamide) is a diuretic most used in clinical practice, neurologists and doctors of other specialties. The drug is synthesized almost 70 years ago. It is possible to get rid of toxic mercury diuretics. Gradually began to be used in the treatment of heart and lung disease, glaucoma, disorders of intracranial pressure.

In subsequent years established and is successfully applied to a large group of specially diuretics to lower blood pressure, taking into account savings of potassium. Great attention is paid to the combined funds that include different combinations of antihypertensive and diuretic drugs.

Diacarb is one of the main drugs in the treatment of hydrocephalus and other pathological disorders of liquor circulation, headaches, sleep apnea (stop breathing) during sleep, such a complex disease, such as family periodic paralysis (also known as Hypo-, normo - and gipercalziemiceski).

The release form and dosage

Acetazolamide tablets are available in blister packs in a dosage of 0.25 g. it Usually matches the assigned one-time admission.

In the treatment of intracranial hypertension is recommended, depending on the clinic and the severity of the condition: 1 tablet per day or ½ – 1 every 8-12 hours. Limit the maximum therapeutic dose of 750 -1000 mg per day.

As Acetazolamide is distributed in organs and tissues of the body?

After taking two tablets inside and zapivaniya water they are well absorbed in the intestine. To achieve the maximum concentration in the blood should pass from 1 to three hours. Further, the content of the preparation falls to be recorded in the plasma of another day.

In the body Diacarb "taken away" from the blood red blood cells, brain tissue, eyeballs, kidneys, muscles. Proven ability to penetrate the placenta and in breast milk.

Accumulation in cells of this substance does not occur. All Acetazolamide is excreted by the kidneys unchanged. Almost 90% of the dose leaving the urine in a day.

The types of brain edema with increased intracranial pressure

The study of disorders at the cellular level in hydrocephalus and increased intracranial pressure revealed that the ultimate cause of pathology are 3 types of swelling of the brain tissue:

1. Vasogenic — caused by increased permeability of the inner endothelial layer of the capillaries, often occurs in hemorrhagic or ischemic stroke, volumetric processes (tumors) in the brain.
2. Cytotoxic — dependent changes in the activity of electrolytes (sodium and potassium) in the composition of the enzyme transmembrane ATPase (ATP), developed with an oxygen deficiency of brain cells, impaired myocardial contractility, meningitis, encephalitis.
3. Interstitial — associated with the retention of fluid and ionssodium in the substance of the brain surrounding the ventricles, a condition called benign intracranial hypertension (pseudo tumor).

The maximum effect of Diacarb manifests itself in the form of interstitial edema.

Details about benign increased intracranial pressure can be learn from this article.

The use of Diacarb for benign cerebral hypertension

Benign form of the disease in the long and in the prevention of recurrence requires the use of Diacarb three times a day. Neuroscientists consider it the drug of first choice.

Clinical studies have shown the successful combination therapy with corticosteroids and Diacarb. A special role is given to the preparation of the restoration by removing the compression from the sheaths of the optic nerve. This allows to save the patient from permanent blindness.

Schemes and features treatment Diakarb

In the treatment of edema of other origin, administered 1 tablet in a day or two. It is important to note that exceeding the dose more than 1 g per day does not increase the result.

In the treatment of glaucoma Diacarb is included in the combination therapy. Depending on the type of disease it is used 1 tablet every 3-4 days or maximum daily dose. Some patients need only two tablets per day.

For children, expect a daily dose of 10-15 mg per kg of body weight and divide it into 3-4 reception. Designate the age of three years. Application diagram: the selected dosage is used for five days, followed by a two-day break. Necessarily the simultaneous appointment of drugs potassium and diet.

Before surgery for glaucoma in the evening is prescribed 2 tablets in the morning again to 500mg.

In the treatment of epilepsy Diacarb adults administered once daily 1-2 tablets three days on the fourth take a break. If necessary, the daily dosage is increased. For children older than three years, the maximum dose was calculated at 8-30 mg / kg of body weight.

When "high-altitude" illness associated with dizziness and nausea when rising to the height of an adult is recommended once a day before climbing to the maximum dose. If necessary, repeat.